Search results for "dominant negative TGFβ type II receptor"

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Susceptibility to collagen-induced arthritis is modulated by TGFβ responsiveness of T cells

2004

The objective of our study was to determine the regulatory effects that endogenous transforming growth factor beta (TGFbeta) exerts on T cells in the pathogenesis of collagen-induced arthritis (CIA). CIA was induced in transgenic mice expressing a dominant negative TGFbeta type II receptor in T cells under the control of the human CD2 promoter. Clinical and histological arthritis scores were determined and experiments on disease induction and the healing phase of disease were performed. The proliferation and cytokine production of draining lymph node cells in vitro were analyzed. Transgenic mice were more susceptible to induction of CIA. The overall incidence was higher in transgenic mice t…

T-LymphocytesMice Inbred StrainsMice Transgenictransgenic miceTh1 CellsArthritis ExperimentalSeverity of Illness Indexdominant negative TGFβ type II receptorArthritis RheumatoidMiceMice Inbred DBATransforming Growth Factor betaAnimalsCytokinesCattleDisease SusceptibilityLymph NodesCollagen Type IICells CulturedCrosses GeneticResearch ArticleIFNγCell ProliferationArthritis Research & Therapy

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